CardiovascularĮmpagliflozin is known to cause osmotic diuresis, leading to intravascular volume contraction and adverse reactions related to volume depletion. Metformin: The most frequently reported side effects included diarrhea, nausea, vomiting, flatulence, abdominal discomfort, indigestion, asthenia, and headache. GeneralĮmpagliflozin: The most frequently reported side effects included urinary tract infections and female genital mycotic infections. ![]() Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.Ĭheck with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More commonĪpplies to empagliflozin / metformin: oral tablet, oral tablet extended release. These side effects may go away during treatment as your body adjusts to the medicine. Some side effects of empagliflozin / metformin may occur that usually do not need medical attention. pain, tenderness, redness, or swelling of the area between the anus and genitals.large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals.dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position. ![]() thick, white vaginal discharge with mild or no odor.redness, itching, swelling, or pain of the penis.itching, stinging, or redness of the vaginal area.difficult, burning, or painful urination.Although not all of these side effects may occur, if they do occur they may need medical attention.Ĭheck with your doctor immediately if any of the following side effects occur while taking empagliflozin / metformin: More common Serious side effects of SynjardyĪlong with its needed effects, empagliflozin / metformin may cause some unwanted effects. Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (eg, carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (eg, acute congestive heart failure), excessive alcohol intake, and hepatic impairment.Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are provided in the full prescribing information.If metformin-associated lactic acidosis is suspected, immediately discontinue empagliflozin/metformin hydrochloride and institute general supportive measures in the hospital setting. Metformin-associated lactic acidosis was characterized by elevated blood lactate levels (greater than 5 mmol/L), anion gap acidosis (without evidence of ketonuria or ketonemia), an increased lactate/pyruvate ratio, and metformin plasma levels generally greater than 5 mcg/mL. The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Lactic AcidosisPostmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias. ![]() Oral route (Tablet Tablet, Extended Release)
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